Obstructive apneas induce early activation of mesenchymal stem cells and enhancement of endothelial wound healing
نویسندگان
چکیده
منابع مشابه
Obstructive apneas induce early activation of mesenchymal stem cells and enhancement of endothelial wound healing
BACKGROUND The aim was to test the hypothesis that the blood serum of rats subjected to recurrent airway obstructions mimicking obstructive sleep apnea (OSA) induces early activation of bone marrow-derived mesenchymal stem cells (MSC) and enhancement of endothelial wound healing. METHODS We studied 30 control rats and 30 rats subjected to recurrent obstructive apneas (60 per hour, lasting 15 ...
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Bone marrow derived mesenchymal stem cells (BM-MSCs) have been shown to enhance wound healing; however, the mechanisms involved are barely understood. In this study, we examined paracrine factors released by BM-MSCs and their effects on the cells participating in wound healing compared to those released by dermal fibroblasts. Analyses of BM-MSCs with Real-Time PCR and of BM-MSC-conditioned medi...
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Background: Mesenchymal stem cells (MSCs) possess a wide range of immunomodulatory functions mostly in immune cells including dendritic cells (DCs). DCs are the key cells in the immune response and play an important role in initiating cell-mediated immunity. Objective: To evaluate the immunomodulatory effects of MSCs supernatant on maturation and function of DCs. Methods: Bone marrow derived m...
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ژورنال
عنوان ژورنال: Respiratory Research
سال: 2010
ISSN: 1465-993X
DOI: 10.1186/1465-9921-11-91